St. John's Wort

St. John's Wort, also known as Hypericum perforatum, is widely recognized for its antidepressant properties, particularly in treating mild to moderate depression. It contains compounds like hypericin and hyperforin that influence neurological functions. Its exact antidepressant mechanism involves neurotransmitter reuptake inhibition and activation of certain cytochrome pathways. However, it interacts with various medications by affecting enzymes in the cytochrome P450 system and P-glycoprotein, potentially altering drug effects. 

St. John's wort is known for its interactions with many medications, including antidepressants, birth control, and certain heart and HIV drugs, potentially leading to serious side effects such as serotonin syndrome and increased sensitivity to sunlight. Given these potential interactions and concerns about its safety, particularly during pregnancy or breastfeeding, it is strongly recommended to seek advice from healthcare professionals before starting St. John's Wort. 

The appropriate dosage of St. John's Wort in milligrams (mg) can vary depending on the specific product and intended use. For individuals seeking mood support or relief from mild to moderate depression and anxiety, a common dosage ranges from 300 mg to 900 mg per day, often divided into two or three doses. However, it's essential to follow the manufacturer's recommended dosage instructions provided on the product label and consult with a healthcare provider for personalized guidance, especially if you have specific mood disorders, are taking other medications, or have underlying health conditions. Professional advice can help ensure you use St. John's Wort at the right dosage for your individual needs, while also monitoring potential interactions and side effects.