Palmitoylethanolamide

Palmitoylethanolamide (PEA) is an endogenously-produced lipid-like molecule that closely resembles endocannabinoids and is derived from fat sources such as egg yolks and peanuts, existing naturally in the human body. Known for its anti-inflammatory properties, PEA has shown efficacy in treating various conditions, including allergies, chronic pain, neurodegeneration, mental disorders, and sleep disturbances. It binds to cells, effectively reducing pain and swelling, making it a potential option for managing different types of pain, fibromyalgia, osteoarthritis, multiple sclerosis (MS), carpal tunnel syndrome, and even conditions like autism. However, while it has been extensively used for these purposes, scientific evidence supporting its effectiveness in many of these applications remains limited. PEA acts as an endogenous fatty acid amide and a lipid modulator, with studies demonstrating its interactions with nuclear receptors, leading to a range of biological effects, particularly linked to chronic inflammation and pain.

The optimal dosage of Palmitoylethanolamide (PEA) can vary depending on individual factors, the specific health concern being addressed, and the formulation of the supplement. Typically, PEA supplements are available in capsules or powder form, with recommended doses ranging from 300 to 1,200 milligrams (mg) per day. It is essential to consult with a healthcare professional or follow the manufacturer's guidelines when determining the appropriate dosage, as individual needs may differ. Starting with a lower dose and gradually increasing it, if necessary, is often a prudent approach to assess how PEA affects one's health and to minimize potential side effects.