Neem

Azadirachta indica, commonly known as neem, is widely recognized as a natural insecticide. Azadirachtin, a crucial compound discovered in the 1960s within neem seed extracts, is well-known for its insecticidal properties. Neem seed oil, containing azadirachtin along with glycerides, polyphenols, nimbolide, triterpenes, and beta-sitosterol, has been traditionally used in Indian medicine for skin issues and rheumatism, although clinical evidence supporting these applications is limited. While Azadirachta indica is incorporated into certain culinary dishes in India, it is not recommended for consumption as a dietary supplement. Neem extracts or oils are not recommended for internal consumption due to potential risks. Short-term external use in adults may be safe, but prolonged internal use may have adverse effects on the kidneys or liver. Neem oil, especially toxic to children, can lead to severe outcomes, including harm to the kidneys, liver. Neem oil can cause complications such as miscarriages, infertility, and low blood sugar. Excessive consumption of neem oil may result in toxic encephalopathy and ophthalmopathy, underscoring the importance of avoiding internal use.