Higenamine

Higenamine, also known as Norcoclaurine, is a compound derived from the Nandina plant traditionally used for its anti-asthmatic properties and currently gaining popularity as a fat burner due to its resemblance to ephedrine's mechanisms. Functioning as a Beta(2) adrenergic agonist, Higenamine has shown potential in dilating bronchial tubes, akin to ephedrine, making it a candidate for fat-burning supplements. Although human evidence is limited, preliminary studies suggest its efficacy in anti-asthmatic effects comparable to established beta(2) adrenergic agonists. Additionally, Higenamine may exhibit anti-inflammatory effects, with potential clinical applications against sepsis. As of April 2019, it is listed on the FDA's Dietary Supplement Ingredient Advisory List, raising questions about its lawful status in dietary supplements. Higenamine's natural occurrence in various plants, including Nandina and lotus species, classifies it as a beta-2 adrenergic receptor agonist, contributing to its use in dietary supplements, pre-workout formulas, and weight loss products.