Examorelin, also known by its developmental code name EP 23905 and commonly referred to as Hexarelin, is a synthetic peptide that functions as a potent, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). It is chemically classified among a group of peptides known as growth hormone-releasing peptides (GHRPs), which stimulate the production and release of growth hormone (GH) from the pituitary gland.
Structurally, Hexarelin is a hexapeptide with the amino acid sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys, which is notable for its strong GH-releasing capability. Its mechanism of action involves mimicking the ghrelin hormone, binding to the GHSR in the pituitary gland, and stimulating the secretion of growth hormone. This process not only enhances the natural production of GH but also plays a role in the modulation of appetite, energy metabolism, and cardiovascular health.
Hexarelin has been studied for its potential applications in various therapeutic areas due to its ability to significantly increase plasma levels of growth hormone. Research has explored its effects on muscle strength, recovery, and metabolism, as well as its potential benefits in improving cardiac function and performance. Unlike some other GHRPs, Hexarelin does not significantly increase cortisol or prolactin levels at doses that stimulate GH release, making it a subject of interest for its targeted action.
Clinical and preclinical studies have investigated the pharmacokinetics, pharmacodynamics, and safety profile of Hexarelin, highlighting its efficacy in stimulating GH secretion without causing significant adverse effects. Its use in research and potential therapeutic applications continues to be explored, particularly in areas related to growth hormone deficiencies, metabolic disorders, and certain aspects of cardiovascular health.
As a research chemical, Hexarelin is primarily used in scientific studies and has not been approved for clinical use by regulatory agencies like the FDA. Its role in advancing our understanding of GH regulation and potential therapeutic applications underscores the importance of peptides in medical research and drug development.