Bushman's Hat

Common Names: Hoodia gordonii, Hoodia, Veldkos, Slimming Cactus, Trichocaulon Gordonii, Stapelia Gordonii

Scientific Names: Hoodia Gordonii

Summary
Hoodia gordonii, commonly known as Bushman's Hat, is a small shrub, often inaccurately described as a cactus, renowned for its claimed appetite-suppressant properties. Despite its historical use by the San Bushmen in the Kalahari Desert to alleviate hunger during extended hunting trips, contemporary research suggests caution in its supplementation. The purported appetite-suppressing molecule, P57, has been identified as the active ingredient in Hoodia. However, studies indicate challenges in P57 reaching the brain to effectively curb appetite, and there are concerns about its potential toxicity. Preliminary studies associated with the plant's introduction to the Western world yielded conflicting results, with the recommended active dose failing to reduce appetite and showing mild toxic effects. While the theoretical mechanism involves P57 acting on the hypothalamus to mimic glucose and signal fullness, current evidence does not support the efficacy of Hoodia gordonii as a promising dietary supplement due to its limited appetite suppression and potential safety issues.